Santa Cruz Vacations from $1,990
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Your Santa Cruz Vacation
Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.
The Latest Santa Cruz Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Aguilas5 SevillaSuites
Historical Center
$2,254
per person
Dec 23 - Dec 29
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Seville (SVQ)
10/10 Exceptional! (530 reviews)
The accommodations were clean, the check in was smooth, and our specific room had a kitchenette with utensils and large fridge. German (Herman) and Jose were outstanding. They are quick to answer questions via WhatsApp or in the lobby. The best part of our stay is the location! A 10 minute walk to Alcazar and the Cathedral, and the “waffle” looking structure. Lots of restaurants downstairs. And Carrefour a few steps away. The suites5 was perfect for our stay in Seville!
Reviewed on Aug 9, 2026
Hotel Boutique Casa del Limonero - Adults only
Historical Center
$3,099
per person
Dec 23 - Dec 29
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Seville (SVQ)
10/10 Exceptional! (97 reviews)
Five stars isn’t enough for this unique hotel. What an amazing experience! Every room and hallway is an art gallery.
Reviewed on Sep 29, 2026
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
8 out of top 10 points of interest in this area
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
El Arenal
Located in Seville's historical center, El Arenal boasts the 13th-century Torre del Oro, Royal Shipyards, and La Real Maestranza bullring. Explore this vibrant area on the Guadalquivir river's east bank.
Alfalfa
Sightsee and feast on local specialties in a part of Seville’s old town district that’s filled with lots of places to eat and socialize.
Triana
Discover traditional pottery and vibrant flamenco culture in this lively area. Shop at Triana Market for local crafts and tapas, or explore Calle Betis for popular restaurants, bars, and nightclubs.
San Bartolomé
Travelers come to San Bartolomé for its lively bars, and you can see top attractions like Pilate's House and Zurbarán Statue while you're in town.
Santa Cruz Hotel Deals
Las Casas de la Judería, Sevilla Historic City Center
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$167 nightly
$184 total
Nov 15 - Nov 16
Total with taxes and fees
9.2/10 Wonderful! (1,018 reviews)
"Loved it here. Very unique, charming property with intriguing nooks and crannies, little courtyards to enjoy, rooftop pool, and a classy but relaxed piano bar. Staff was excellent, professional yet friendly. Would recommend."
Reviewed on Oct 15, 2026
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$553 nightly
$608 total
Nov 9 - Nov 10
Total with taxes and fees
Hotel Amadeus Sevilla
Calle Farnesio 6 Seville Seville
Fully refundableReserve now, pay when you stay
$153 nightly
$168 total
Nov 15 - Nov 16
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Santa Cruz attractions
Royal Alcázar of Seville
9.6/10 (8,220 reviews)
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
9.4/10 (6,353 reviews)
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Triunfo Plaza
9.6/10 (18 reviews)
From this ancient and picturesque square, access some of the oldest and most impressive buildings in Seville, including the world’s largest gothic cathedral.
University of Seville
8.6/10 (1,316 reviews)
Enjoy the collegiate vibe when you visit University of Seville, during your travels in Paseo de Las Delicias. Visit the stunning cathedral and shops in this culturally rich area.
Santa Cruz Church
8.6/10 (26 reviews)
After visiting Santa Cruz Church, make a plan to see the other sights and activities in Seville. Check out the shops and top-notch restaurants in this romantic area.
General Archive of the Indies
8.0/10 (11 reviews)
You can study the exhibits at General Archive of the Indies, a museum with a story of its own, during your travels to Seville. Check out the stunning cathedral and lively bars in this culturally rich area.
Puerta del Príncipe
10.0/10 (2 reviews)
Find out about the history of Seville when you take a trip to Puerta del Príncipe. Check out the stunning cathedral and lively bars in this culturally rich area.
Things to do
Seville: Guadalquivir River Cruise
$21
per adult
80% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
$34
per adult
88% of travellers recommend
Seville: Setas de Sevilla Entry Ticket
$18
per adult
80% of travellers recommend
Explore a world of travel with Expedia
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.