Santa Cruz Vacations from $169

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Vértice Aljarafe
Aguilas5 SevillaSuites
Welldone Cathedral
Welldone Quality - Crystal Pool
Casa del Gitano by Época Suites

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz

Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $124 total per night from Dec 9 to Dec 10
$124 total
Dec 9 - Dec 10
Total with taxes and fees
9.2/10 Wonderful! (1,001 reviews)
A fantastic hotel with so much charm .. A beautiful room with a hydro bath which was very much enjoyed after 18000 steps …

Reviewed on Nov 6, 2025

Las Casas de la Judería, Sevilla Historic City Center
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $140 total per night from Dec 1 to Dec 2
$140 total
Dec 1 - Dec 2
Total with taxes and fees
9.4/10 Exceptional! (1,092 reviews)
The hotel is spotless and the staff so helpful and friendly. The location is perfect to explore Seville on foot and I would not hesitate to stay there again.

Reviewed on Nov 13, 2025

Hotel Rey Alfonso X
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $126 total per night from Dec 10 to Dec 11
$126 total
Dec 10 - Dec 11
Total with taxes and fees
9.6/10 Exceptional! (1,522 reviews)
Great location & staff were wonderful!

Reviewed on Nov 17, 2025

Hotel Fernando III
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Cruz

Things to do

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.